Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening
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چکیده
منابع مشابه
Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening
Identifying "druggable" targets and their corresponding therapeutic agents are two fundamental challenges in drug discovery research. The one-bead-one-compound (OBOC) combinatorial library method has been developed to discover peptides or small molecules that bind to a specific target protein or elicit a specific cellular response. The phage display cDNA expression proteome library method has b...
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ژورنال
عنوان ژورنال: ACS Combinatorial Science
سال: 2016
ISSN: 2156-8952,2156-8944
DOI: 10.1021/acscombsci.5b00194